Have you been using any over-the-counter medicine for your toothache, gum pain, or oral wounds?

If you happen to use it any time from now, make sure to check if it contains benzocaine.

Benzocaine (5-20%) is a local anesthetic that comes in different formulations (spray, gel, ointment, paste) and is commonly used for intraoral use. You might use it as Orajel or Anbesol.

It numbs the area of application and thus alleviates pain.

While local side effects such as edema, irritation, and redness are common side effects and get subsided mostly on their own, there’s one rare condition that can often be life-threatening: Methemoglobinemia.

Methemoglobinemia is a condition in which the oxygen-carrying capacity of hemoglobin is reduced. People with breathing problems, heart disease, and the elderly are at greater risk of developing the condition.

FDA has reported over 400 cases of benzocaine-induced-methemoglobinemia since 1971.

Upon the appearance of any symptoms like the pale, bluish-gray coloration of the skin, lightheadedness, fatigue, or rapid heartbeat, you need immediate clinical attention.

However, the chance of developing this condition is rare always be alert if any suspicious adverse effect appears.

Remember, such medications are only for immediate symptomatic relief and not an ultimate cure.

If pain persists over a week, you should consider seeing a dentist or doctor.

Additional note, the use of such formulation is contraindicated in children below two years of age.

 

I am Gaurav Rayamajhi, PharmD, a medical writer, and presenter. I create comprehensive meaningful medical content for patients, healthcare professionals, and health service industries.